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PANEXIA®: Hereditary Testing for Pancreatic Cancer

PANEXIA® is a genetic test specifically created to detect mutations in genes that result in an increased risk of pancreatic cancer, offering insight about the risk of future hereditary cancers for patients and their families. PANEXIA, via a simple blood test, analyzes the PALB2 and BRCA2 genes, the two genes most commonly identified in families with hereditary pancreatic cancer.

The PANEXIA test results provide information for patients and their family members about the inherited risks of pancreatic cancer as well as breast, ovarian, and other cancers. This knowledge may allow at-risk family members the opportunity to lower their risks for some of these cancers through surveillance, preventative options, or lifestyle choices.

Benefits of PANEXIA Testing

The results of the PANEXIA test enable the development of a patient-specific medical management plan to reduce the risk of cancer.  PANEXIA helps to:

  • Target screening and surveillance specifically to individuals with a PALB2 or BRCA2 gene mutation
  • Improve patient and their family members' compliance with tailored screening recommendations and preventive measures
  • Improve outcomes through prevention, earlier diagnosis and treatment of specific cancers, should they develop
  • Counsel patients and their family members on the underlying cause of mutation-related cancers in their family
  • Avoid unnecessary interventions for family members who do not test positive for the mutation known to be in the family

Medical Management and PANEXIA

If PANEXIA testing confirms the presence of a PALB2 or BRCA2 mutation, the following medical management options may help reduce cancer risk and may either delay the onset of cancer, detect cancer at an earlier, more treatable stage or even prevent it.

Positive PALB2 Gene Mutation Result:

  • Increased surveillance for pancreatic cancer
  • Increased surveillance for breast cancer

Positive BRCA2 Gene Mutation Results:

  • Increased surveillance for pancreatic cancer
  • Increased surveillance for breast cancer
  • Increased surveillance for ovarian cancer
  • Risk Reducing Medications
  • Prophylactic surgery

NOTE: Any discussion of medical management options is for general informational purposes only and does not constitute a recommendation.  While genetic testing and medical society guidelines provide important and useful information, medical management decisions should be made based on consultation between each patient and his or her healthcare provider.

 

Myriad has developed a Hereditary Cancer Quiz you can use with your patients to help identify who is a candidate for genetic testing using PANEXIA.

Hereditary cancer quiz

 

For more physician information or to order a PANEXIA text kit, please visit MyriadPro

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